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Thus, he started believing that his wife was definitely having extramarital relations and that she was a characterless lady, despite repeated clarifications from her. Though this case illustrated the successful effect of sildenafil on sexual dysfunction and associated jealousy, a systematic study is needed to generalize the finding to prove that there may be a subgroup of morbid jealousy cases with sexual dysfunction which may order sildenafil citrate respond to this drug. The inhibition of PDE5 in these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of nitric oxide observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo.