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In theory, you should be able to apply retinol to the skin, wait till it gets converted to retinoic acid, and eventually get the known skin benefits of the latter. Since acne can be triggered by fluctuating hormone levels within the body, it stands to reason that acne can appear at the various stages in life when hormone levels are changing such as puberty, pregnancy and menopause. Damaging effects on the fetus have been described in animals receiving oral tretinoin.
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